From Viagra to Valium, the drugs that were discovered by accident
From Alexander Fleming onwards, the lives of millions have been transformed and saved by treatments that scientists were not even looking for

A number of major scientific discoveries have been down to pure chance. Photograph: Blend Images, ER Productions Ltd/Getty Images
James Rudd-Tuesday 11 July 2017
When scientists in New Zealand discovered that a meningitis vaccine fortuitously protects against gonorrhoea, they were benefiting from an unpredictable force responsible for some of history’s most striking medical breakthroughs: serendipity.
So many things have been discovered by chance. The German writer, scientist and all-round polymath Johann Wolfgang Goethe, a discoverer himself, wrote: “Discovery needs luck, invention, intellect – none can do without the other.”
During early clinical trials of sildenafil, now better known by its trade name Viagra, male volunteers taking the pills consistently reported unprovoked, long-lasting erections. After further investigation, it turned out that Viagra, designed to relax blood vessels around the heart to improve blood flow, was having the same effect on arteries within the penis. Since its commercial release in 1998, it has been used to improve the sex lives of millions of men worldwide.
Incidentally, the 2007 ‘Ig’ Nobel Prize, awarded annually for that year’s most useless research, was awarded to three Argentinian scientists who discovered that Viagra helped hamsters recover faster from jet-lag.
In Fleming’s absence, the dish, growing the dangerous bacteria Staphylococcus aureus, had become contaminated with an air-borne mould – a type of fungus. Fleming noticed that, near the blue-green strands of fungus, growth of the bacteria had been stopped in its tracks.
Fleming had inadvertently stumbled across the first antibiotic, which he called penicillin.
For his accidental discovery, he shared the Nobel prize for medicine in 1945 with Florey and Chain, Oxford chemists who perfected the process of penicillin mass production in time to treat infected battlefield injuries sustained in the second world war.
“When I woke up just after dawn on 28 September, 1928, I certainly didn’t plan to revolutionise all medicine by discovering the world’s first antibiotic, or bacteria killer,” Fleming later recalled. “But I suppose that was exactly what I did.”
While trying to build a device to record heartbeats in 1956, he accidentally installed the wrong type of resistor into his prototype – which promptly began to emit regular electrical pulses.
Realising these pulses were recapitulating the electrical activity of a normal heartbeat, Greatbatch immediately saw the potential of his device. After two years of refinements, his design for a pacemaker that could be implanted into the heart was patented in 1960 and soon went into production. Life-saving descendants of this first device now improve the lives of over half a million patients with slow heartbeats every year.
To prove their hunch, Marshall deliberately downed a pint of foaming helicobacter broth that he’d grown in his lab after isolating it from the stomach of one of his patients. Within a week, he had rampant stomach inflammation – which was then completely reversed by taking antibiotics.
Their discovery has also meant the virtual eradication of a type of stomach cancer caused by helicobacter infection.
For their work (and presumably Marshall’s bravery), Marshall and Warren were awarded the 2005 Nobel prize for medicine.
The dyes were a failure. The benzodiazapines quickly became the most popular prescription drugs in the US.

A number of major scientific discoveries have been down to pure chance. Photograph: Blend Images, ER Productions Ltd/Getty Images
James Rudd-Tuesday 11 July 2017When scientists in New Zealand discovered that a meningitis vaccine fortuitously protects against gonorrhoea, they were benefiting from an unpredictable force responsible for some of history’s most striking medical breakthroughs: serendipity.
So many things have been discovered by chance. The German writer, scientist and all-round polymath Johann Wolfgang Goethe, a discoverer himself, wrote: “Discovery needs luck, invention, intellect – none can do without the other.”
Viagra
In pharmaceutical giant Pfizer’s laboratories in Kent, a failed treatment for angina accidentally became a billion-dollar erectile dysfunction blockbuster, and the world’s most famous blue pill.During early clinical trials of sildenafil, now better known by its trade name Viagra, male volunteers taking the pills consistently reported unprovoked, long-lasting erections. After further investigation, it turned out that Viagra, designed to relax blood vessels around the heart to improve blood flow, was having the same effect on arteries within the penis. Since its commercial release in 1998, it has been used to improve the sex lives of millions of men worldwide.
Incidentally, the 2007 ‘Ig’ Nobel Prize, awarded annually for that year’s most useless research, was awarded to three Argentinian scientists who discovered that Viagra helped hamsters recover faster from jet-lag.
Penicillin
Returning to work after a month-long Scottish vacation in 1928, pathologist Alexander Fleming made a discovery in a discarded culture dish, which he had unintentionally left open to the elements on a window sill in his laboratory at St Mary’s Hospital in London.In Fleming’s absence, the dish, growing the dangerous bacteria Staphylococcus aureus, had become contaminated with an air-borne mould – a type of fungus. Fleming noticed that, near the blue-green strands of fungus, growth of the bacteria had been stopped in its tracks.
Fleming had inadvertently stumbled across the first antibiotic, which he called penicillin.
For his accidental discovery, he shared the Nobel prize for medicine in 1945 with Florey and Chain, Oxford chemists who perfected the process of penicillin mass production in time to treat infected battlefield injuries sustained in the second world war.
“When I woke up just after dawn on 28 September, 1928, I certainly didn’t plan to revolutionise all medicine by discovering the world’s first antibiotic, or bacteria killer,” Fleming later recalled. “But I suppose that was exactly what I did.”
Heart pacemaker
New York engineer Wilson Greatbatch invented the world’s first implantable heart pacemaker – but he didn’t mean to.While trying to build a device to record heartbeats in 1956, he accidentally installed the wrong type of resistor into his prototype – which promptly began to emit regular electrical pulses.
Realising these pulses were recapitulating the electrical activity of a normal heartbeat, Greatbatch immediately saw the potential of his device. After two years of refinements, his design for a pacemaker that could be implanted into the heart was patented in 1960 and soon went into production. Life-saving descendants of this first device now improve the lives of over half a million patients with slow heartbeats every year.
Stomach ulcers
In the 1980s, two Australian doctors were ridiculed for suggesting that stomach ulcers were caused not by business lunches and stress, but by infection with a common bacteria. Barry Marshall, a gastroenterologist and his pathologist colleague in Perth, Robin Warren, noticed that stomach biopsies taken from their ulcer patients all contained the same spiral-shaped bacteria, called Helicobacter pylori.To prove their hunch, Marshall deliberately downed a pint of foaming helicobacter broth that he’d grown in his lab after isolating it from the stomach of one of his patients. Within a week, he had rampant stomach inflammation – which was then completely reversed by taking antibiotics.
Their discovery has also meant the virtual eradication of a type of stomach cancer caused by helicobacter infection.
For their work (and presumably Marshall’s bravery), Marshall and Warren were awarded the 2005 Nobel prize for medicine.
Antidepressants
Several classes of antidepressants owe their discovery to chance, from iproniazid, which was initially used to treat tuberculosis in the 1950s, to the tricyclics of the 1960s, which stemmed from an experimental treatment for schizophrenia and the more recent breakthrough involving the use of ketamine.Valium
The entry-level benzodiazapine was developed in the 1950s by a Polish immigrant in the US, Leo Sternbach, from discarded chemical compounds he had synthesised 20 years earlier in Poland when he was working on experiments to create new dyes.The dyes were a failure. The benzodiazapines quickly became the most popular prescription drugs in the US.












Pardon me if I have got this wrong, but you were reported as having said that anyone watching television would feel that there was no government in the country. I don’t know how you came to this conclusion by watching television, but we had the same thought – even without watching television!
So, are we to now believe that what he was saying – that certain communities were second class people in this country and should be treated differently – was right? Please correct me if I am wrong but that is different from the Buddhism I know which says one is an outcast or a noble not by birth but by deed.

not allowed to reveal details of the discussion. But I can tell you that last week the Steering Committee met thrice and we are now discussing the draft interim report, clause by clause. We have finished almost half of the report. We hope to finish the rest in the month of July. Hopefully there will be an interim report within the next few weeks. 



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from the decisions taken during the Rajapaksa presidency -- though that does not mean they were all bad decisions. What is disingenuous however is that Mr. Rajapaksa is now behaving as if he was born yesterday and is instigating the people against those very decisions. Poor souls who have now been taken for a ride by the born-again Mr Rajapaksa could well have been offered a free ride in a white van, had they chosen to challenge those decisions during the Rajapaksa presidency. Even the Mahanayakas were careful not to cross the red line with him. In 2010, after the arrest of General Sarath Fonkseka, the Mahanayakas planned to convene a Sanga convention to highlight their concerns over the mistreatment of the war-winning former army chief and the erosion of democracy in the country. After one ominous telephone call from Mr Rajapaksa, who allegedly threatened to split an existing Nikaya into two, Buddhist high priests abandoned all plans and went into a half decade of hibernation. Recently, they appeared to have been woken up by a courier from the ex-president. 